Step one: get rid of Internet explorer (Improves security by 9000%)
Step two: Get Firefox or Chrome with adblock plus
Step three: Download Peerblock and use it with sketchy webpages
Step four: Be careful what website you visit and be even more careful what links you click.
Step five: Live a virus-free life
That should do the trick.
As for the virus, this seems to explain how to get rid of it:
http://zondervirus.nl/delta-homes-com/