On recent AMD videocards you can use Eyefinity to run Ship Simulator on up to 6 displays. But having played Ship Simulator at a quad monitor 3840x2160 resolution I can tell that you need a serious videocard to handle so many pixels, two Radeon HD 6970 cards in a CrossFireX setup did the trick. Also with the Eyefinity setup you are limited to showing the game over multiple monitors, you can't use one screen for the radar/chart/control and the other one for the 3D view.
